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PHCEU Course Descriptions
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University of Utah

General Catalog Fall 2012
Posted Mar 02, 2012

Disclaimer: The course information below is current as of Mar 02, 2012, is intended for informational purposes only, and does not constitute a legal contract between the University of Utah and any person or entity.

This Web document is updated twice a year, on or about the first day of registration for Fall and Spring semesters.

5125  Dosage Forms and Drug Delivery Systems (4) Prerequisite: Professional Pharmacy Student.
   Physicochemical approach to stability and performance of pharmaceutical dosage forms. Mathematics, thermodynamics, coligative properties, solubility, chemical equilibrium and kinetics. Emphasis on interfacial phenomena as applied to pharmaceutical dosage forms including suspensions, emulsions, creams, ointments, and advanced delivery systems.

5611  Practical Aspects of Intravenous Drug Delivery (1) Prerequisite: Professional Pharmacy Student.
   Course will teach professional pharmacy students technical and physiologic issues that are important to understand and consider when administering drugs by intravenous infusion.

5880  Journal Club in Pharmaceutics (1) Prerequisite: Professional Pharmacy Student.
   Reports from current pharmaceutics and related literature.

5960  Special Problems in Pharmaceutics (1 to 3) Prerequisite: Professional Pharmacy Student.
   Conferences, library, and laboratory work by arrangement.

5980  Faculty Consultation (1) Prerequisite: Professional Pharmacy Student.

6020  Biomaterials (3) Cross listed as BIOEN 6302.
   Chemical, physical, and biological properties of synthetic polymer, metal, and ceramic biomaterials. Relationship between the structure of biomaterials and their interaction with blood, soft, and hard tissue. Mechanical properties, fabrication, and degradation mechanisms, and performance testing of materials in biomedical use.

6612  Clinical Research and Drug Development: From Molecule to Market (1)
   This is an elective course for pharmacy students which will review the process of new drug development and expose students to the opportunities that exist within the pharmaceutical industry for people with pharmaceutical training and expertise. This course will review in a general manner of what is required to take a new drug entity, a molecule, from discovery through to the market with an emphasis on the clinical research aspects.

6880  Journal Club in Pharmaceutics (1)
   Reports from current pharmaceutics and related literature.

6890  Research Seminar (1)
   Seminar on personal research or assigned literature surveys.

6960  Special Problems in Pharmaceutics (1 to 3)
   Conferences, library, and laboratory work by arrangement.

6970  Thesis Research: Master's (1 to 12)

6980  Faculty Consultation: Master's (3)
   Arranged as needed by master's candidates.

7010  Molecular Biology for Pharmaceutical Scientists (1.5) Prerequisite: Graduate Standing.
   This course will review fundamental aspects of genetic engineering and molecular biology, with application to health sciences.

7011  Pharmacokinetic Modeling (1.5) Prerequisite: PHCEU 7010, or Special Permission from Instructor.
   This course will review fundamental aspects of pharmacokinetics with an emphasis on understanding concepts for compartmental and non-compartmental modeling, physiologic modeling, and modeling of targeted drug delivery systems. The goal of the course is to understand how these techniques can be used to optimize drug delivery.

7020  Advanced Physical Pharmacy and Drug Formulations (4) Prerequisite: Graduate student status or instructor consent and CHEM 7050.
   Physicochemical fundamentals of dosage form design. Molecular thermodynamics approach to establishing principles of solutions, structures of liquids and solids, complexation, ion-solvent interactions, and multiple equilibria of organic solutes. Physicochemical examination of peptides and proteins, and protein structures. Thermodynamics of nucleic acids: temperature effects, cooperativity, and hybridization equilibria. Principles of colloid and interfacial sciences applied to pharmaceutical dosage formulations.

7030  Macromolecular Therapeutics and Drug Delivery (4) Prerequisite: Graduate student status or instructor consent and CHEM 7050.
   Introduction to polymer in Pharmaceutics and drug delivery. Transport phenomena in drug delivery systems. Macromolecular and vesicular carriers. Biorecognition and drug targeting. Protein, oligonucleotide, and gene delivery systems.

7031  Lipid-based Drug Delivery Systems (0.5 to 2) Prerequisite: Graduate student status and PHCEU 7030, or instructor consent.
   Introduction to lipid systems in Pharmaceutics and drug delivery. Emulsions, micellar and vesicular carriers. Biorecognition and drug targeting of small molecule, protein, and nucleic acid therapeutics.

7040  Biotechnology (4) Prerequisite: Graduate student status or instructor consent and one differential equations course.
   Principles of kinetics and mechanisms of organic reactions and structure-reactivity relationships applied to pharmaceutical systems. Mechanisms of the degradation and stabilization of drugs, proteins, and DNA.

7055  Integrated Drug Development Process in the Pharmaceutical Industry (1.5)
   This course covers Drug candidate selection, Form selection (salt/polymorph), Preformulation, Dosage form Design, Dosage form strategy, Formulation evaluation, Equipment and processing, Formulation and process optimization, scale-up and validation.

7095  Molecular Modeling and Biomolecular Simulation from a Pharmaceutical Perspective (2) Cross listed as MD CH 7095.
   This survey course, including a hands-on component, will cover computational and simulation methods for understanding the structure, dynamics and interactions of biological molecules with an emphasis on topics relevant to therapeutic design, delivery and disposition. Possible topics will include molecular modeling, atomistic simulation, molecular docking, drug design, ADME, homology modeling, high performance computing, and protein structure prediction. We will first review fundamental principles of molecular interaction and then survey various modeling approaches to highlight their ranges of applicability and limitations. Experience with computers is desirable for the laboratory component.

7110  Molecular Imaging (2) Prerequisite: General Chemistry.
   This elective will introduce the concepts and principles of molecular imaging and its application to Phar. D. and Ph.D. students. The course will prepare students familiar with basic physics of clinical imaging modalities. The main focus of the course will be the imaging probes or contrast agents used for these imaging modalities and their applications.

7210  Biocompatibility (2) Cross listed as BIOEN 7120.
   Biocompatibility of soluble and insoluble (crosslinked) polymers. Biocompatibility of biomaterials used as implants, blood substitutes, and carriers of bioactive molecules. Biorecognition of synthetic macromolecules on cellular and subcellular levels. Biodegradability and immunogenicity of biomaterials.

7220  Pharmaceutical Applications of Colloid and Interfacial Science (2) Cross listed as BIOEN 7130. Prerequisite: Graduate student status or instructor consent and PHCEU 7020.
   Colloid, interfacial, and electrokinetic theories applied to the design of drug formulations, drug delivery, and therapeutic efficacy.

7230  Nanomedicine (3)
   Meets with BIOEN 6405. The convergence of recent advances in nanotechnology with modern biology and medicine has created the new research domain of nanobiotechnology. The use in medicine is termed nanomedicine. Nanomedicine research includes the development of diagnostics for rapid monitoring, targeted cancer therapies, localized drug delivery, improved cell material interactions, scaffolds for tissue engineering, and gene delivery systems among others. Successful research and development in nanomedicine where ultimately patients and the general public can benefit from these new technologies require the interaction of a multitude of disciplines including chemistry, materials science and engineering, cellular biology, pharmaceutical sciences and clinical translational research. This course will span the spectrum of how such materials are fabricated, characterized, interact with the biological environment, used in specific biomedical applications and translated from concept to the clinic and commercialization. Topics are taught by experts in the respective areas and will include fundamentals of nanomedicine, bottom up and top down approaches to nanofabrication, conjugation strategies, physiochemical characterization, cellular uptake and toxicity, biodistribution, clinical and preclinical nanomedicine as well as special topics in nanobiosensors, nanofluidics, polymer therapeutics and commercialization of nanomedicine products. This course will count as an elective for the Nanotechnology Graduate Programs and potentially other departmental graduate programs at the University of Utah.

7310  Biomembrane Transport (2) Prerequisite: Graduate student status and PHCEU 7010 and 7020.
   Applications of diffusion and transport theory to drug permeation across lipid bilayers, cultured cells, gastrointestinal tract, skin, and the blood-brain barrier.

7315  Biopharmaceutics and Pharmacokinetics (2) Prerequisite: Doctor of Pharmacy Student or graduate students status or instructor consent.
   Characterization of the time course of drug absorption, distribution, metabolism, and excretion. The relationship to intensity and time course of drug effects. Design of dosage regiments in selected disease states. Role of pharmacokinetics involved in individualized drug therapy.

7316  Applied Clinical Pharmacokinetics (2) Prerequisite: Professional Pharmacy Student.
   Application of principles of pharmacokinetics and pharmacodynamics to the individualization of pharmacotherapy.

7410  Physicochemical Approach to Proteins and Nucleic Acids (3) Cross listed as BIOEN 7111. Prerequisite: Graduate student status or instructor consent and PHCEU 7020.
   Applying physicochemical theory and molecular modeling to protein, peptide, and nucleic acid structure and stabilization.

7420  Delivery of Macromolecular Therapeutic Agents (2) Prerequisite: Graduate student status and PHCEU 7010 and 7020.
   Applying physicochemical principles to the delivery of macromolecular therapeutic systems including antisense-mediated gene inhibition and gene therapy.

7430  Analytical Techniques (2) Prerequisite: Graduate Student Status and PHCEU 7020.
   Applying fundamental bioorganic, analytical, and surface chemistry to the development of biosensors for drug and metabolite analysis.

7510  Pharmacokinetic Approaches to Drug Delivery (2)
   Design and analysis of pre-clinical pharmacokinetic and pharmacodynamic studies.

7520  Mathematical Modeling of Pharmaceutical Systems (2)
   Integrated approach to biophysical and pharmacological concepts underlying design and performance of controlled-release dosage forms. Modern numerical and mathematical techniques analysis of physicochemical models for drug transport, pharmacokinetics, metabolism and pharmacodynamics.

7530  Animal Studies and Human Subjects in Pharmaceutical Research (2) Prerequisite: Graduate Status and PHCEU 7010.
   Surgical techniques to evaluate absorption, metabolism, pharmacokinetic and pharmacodynamic characteristics of drug formulations for pre-clinical studies.

7890  Research Seminar in Pharmaceutics (1)
   Seminar on personal research or assigned literature surveys.

7950  Research Clerkship (6) Prerequisite: Professional Pharmacy Student.
   Six week research rotation involved in clinical, experimental, and analytical research. Students must obtain instructor approval to register.

7960  Special Problems in Pharmaceutics (1 to 3)
   Conferences, library, and laboratory work as arranged.

7970  Thesis Research: Ph.D. (0.5 to 12)

7975  Journal Club in Pharmaceutics (1)
   Reports from current pharmaceutics and related literature.

7980  Faculty Consultation: Ph.D. (3)
   Arranged as required by graduate students.

7990  Continuing Registration: Ph.D. (0)

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