This Web document is updated twice a year, on or about the first day of registration for Fall and Spring semesters.

1102  Fundamentals of Bioengineering II (3) Co-requisite: MATH 1260 or MATH 1220 and CHEM 1220.
   This course continues the bioengineering introductory sequence. The course places an emphasis on biochemistry and bioenergetics and molecular transport, electrochemical gradients, heat and mass transport, and related topics are use to develop basic principles in cellular, organ, and systemic physiology.

1510  Science Without Walls: Science in Your World (3) Fulfills Physical/Life Science Exploration.
   A concept- and inquiry-based television course which focuses on major concepts covering to all areas of science. The course is multi- and interdisciplinary and designed primarily for nonscience majors. It connects science to daily life and activities, including the connections between the sciences, arts, and the humanities.

2000  Careers in Biomedical Engineering (1)
   NOTE: GRADING CR/NC This seminar series will introduce students to various career opportunities in the field of biomedical engineering. Guest speakers from industry, clinical practice, and research will discuss aspects of their professional practice, including global, ethical and health-care issues. Each student writes a paper on career choices of potential interest to them in biomedical engineering.

3070  Applied Math and Statistics for Bioengineers (3) Cross listed as BIOEN 5070. Prerequisite: MATH 1220 or 1250.
   Introductory course will cover concepts from probability and statistics. Topics will include discrete and continuous random variable, distributions, univariate and multivariate distributions, expected values, moments, normal distribution, and derived distribution; maximum likelihood estimation, confidence intervals, and tests of hypotheses. Graduate students will be given extra projects to exemplify concepts learned.

3201  Biomolecular Engineering (4) Prerequisite: BIOL 2020 and CHEM 2320.
   Meets with BIOEN 5170 and 7170. This course is the first in a two-semester sequence in Human Physiology. The 1st semester begins at the molecular scale and progresses rapidly to the systems scale. Throughout, emphasis is placed on molecular structures and mechanisms. the course has an associated laboratory with exercise related to lecture topics.

3202  Physiology for Engineers (4)
   This course is the second in a two-semester sequence (BIOEN 3201, 3202, Human Physiology I, II) that teaches students to apply knowledge of mathematics, science, and engineering to cellular and systems physiology, including function, dysfunction, and the mechanisms that underlie treatment. The course also addresses professional and ethical responsibility associated with the development, testing, and implementation (or withholding) of biomedical devices or treatments. Associated laboratory modules teach students to design, conduct, and analyze experiments, and to use the techniques, skills and tools necessary for engineering practice. Topics this semester include the nervous system, striated and smooth muscle, and respiratory, renal, and cardiovascular systems.

3301  Computation Methods for Bioengineers (3) Prerequisite: MATH 1250, 1260 and 2250 (or equivalent).
   Computers are increasingly indispensable in biomedical engineering research for data acquisition, analysis and modeling. For students that will not have received any programming training, the course covers basic computation skills including data representation, storage, display, descriptive statistics, numerical analysis theory, optimization, and other relevant topics via hands-on exercises based on real biomedical engineering applications. A high-level multi-purpose scientific computing package (e.g., Matlab) will be used.

3801  Biomedical Engineering Design I (3) Prerequisite: PHYS 2210, CHEM 2310, MATH 2250 or instructor's permission.
   Biomedical engineering design covered from an FDA design perspective. Topics include team building, literature searches, and project management. Discussions on economic, environmental, sustainability, manufacturability, ethical, health and safety, social, and political considerations will be included. Students will be assigned to a group to work on a design project that will continue into BIOEN 4801 and will also select and start their BME senior projects for BIOEN 4201. Lecture: 2 hours and Lab: 3 hours.

3900  Special Topics (3) Prerequisite: See department.
   Introductory course will cover concepts from probability and statistics. Topics will include discrete and continuous random variable, distributions, univariate and multivariate distributions, expected values, moments, normal distribution, and derived distribution; maximum likelihood estimation, confidence intervals, and tests of hypotheses.

4103  Bioengineering Laboratory III (1) Prerequisite: BIOEN 3102.
   The course provides laboratory exercises to compliment the material presented in the lectures associated with the other required Bioengineering classes taught the same semester (BIOEN 5101).

4104  Bioengineering Laboratory IV (1) Prerequisite: BIOEN 3201, 3202.
   This course provides laboratory experience that complements the concurrently running BIOEN 5301, Biomaterials course.

4201  Bioengineering Project I (2) Prerequisite: Restricted to students in their fourth year of the program.
   This course uses each student's required senior project as source information that the student will repeatedly present to the class in both a written and oral format. Due the communication emphasis of the class, it along with BIOEN 4202 covers the University's upper-division communication/writing requirement. During the course of the class, each student provides several oral presentations that are followed-up with instructional criticism from the class and the instructor. The students also prepare a progress report and a draft version of their final project poster at the conclusion of the semester that are critiqued and returned at the start of BIOEN 4202 for revision and resubmission.

4202  Bioengineering Project II (3) Prerequisite: BIOEN 4201. Fulfills Upper Division Communication/Writing.
   This course is a continuation of BIOEN 4201 where each student was required to present his or her senior project. The class requires each student to further refine both the oral and written presentation of his or her senior project to a professional level through additional presentations in several different time formats and through submitted drafts of his or her senior thesis. Due to the communication emphasis of the class, it along with BIOEN 4201 covers the University's upper-division communication/writing requirement. At the conclusion of the semester, each student provides a senior thesis and participates in a public senior project fair where they provide a five-minute oral presentation followed by a twenty-minute poster presentation.

4801  Biomedical Engineering Design II (3) Prerequisite: BIOEN 3801or instructor's permission.
   Continuation of BIOEN 3801. Initial designs will be prototyped before going through a design review. Design validation issues and improvements will then be solved in a redesign phase following a design process based on FDA-QSR. Projects will be team oriented and lead to increased project management skills. In addition, discussions on design considerations will continue. A final written design document and an oral presentation of the working prototype will culminate the class. Lecture: 1 hour and Lab: 6 hours.

4990  Internships and Co-ops (1 to 3) Prerequisite: Department approval and Major status.
   This directed study course is designed to provide academic credit for internships and co-op experiences in bio-, biomedical engineering and closely related fields. Students must submit a written proposal describing the work to be completed for course credit to the instructor to obtain permission to enroll. The proposal must also include a brief description of the sponsor including contact information for the student's immediate supervisor. Proposals are evaluated and approved for course credit on the basis of programmatic educational merit.

4999  Honors Thesis/Project (3) Pre-requisite: BIOEN Major status.
   Restriced to students in the Honors Program working on their Honors degree.

5001  Biophysics (4) Prerequisite: MATH 2250 and PHYS 2220. Fulfills Quantitative Intensive BS.
   This intermediate-level 4 credit-hour course is focused on the application of physical principles to 1) develop quantitative understanding of biophysical processes in natural and engineered molecules, membranes, tissues and organs and to 2) apply biophysical principles to the solution of biomedical engineering problems related to health and the human condition.

5020  Interactive Science Exhibits (1 to 3)
   An independent project course involving the design, development, implementation, and testing of interactive science/technology exhibits/activities for science centers or museums. Students may work individually or in groups.

5030  From Biology to Engineering (2)
   This directed reading/discussion project course in the area of biobased engineering is designed for advanced undergraduate and graduate students without biology backgrounds. The course rapidly surveys modern biology and then focuses on unique phenomena with potential engineering applications, such as bioluminescence, photosynthesis, bio-hydrogen, anhydrobiosis, salt glands, thermogenesis, extremophilia, electric organs, and wall-forming organisms.

5070  Applied Math and Statistics for Bioengineers (3) Cross listed as BIOEN 3070. Prerequisite: MATH 1220 or 1250.
   Introductory course will cover concepts from probability and statistics. Topics will include discrete and continuous random variable, distributions, univariate and multivariate distributions, expected values, moments, normal distribution, and derived distribution; maximum likelihood estimation, confidence intervals, and tests of hypotheses. Graduate students will be given extra projects to exemplify concepts learned.

5090  Biophysical Chemistry (3) Cross listed as CHEM 3090. Recommended Prerequisite: CHEM 1220 and PHYS 2220 and MATH 2210. Fulfills Quantitative Intensive BS.
   Emphasizes biological and biochemical aspects of physical chemistry.

5091  Current Research in Bioengineering (1)
   Seminar in biomedical engineering and bioengineering where faculty present highlights of their current research. The seminar is intended to introduce students to current research in the field and to help students identify potential graduate or undergraduate research projects.

5101  Engineering Principles in Bioinstrumentation (4) Prerequisite: PHYS 2220, MATH 2250.
   The fundamentals of bioinstrumentation: sources of biological signals, physics of biosignal transducers, analog and digital circuit elements, basic electrical circuit theory, signal conditioning, and signal analysis techniques. Includes laboratory experience in material covered in lecture.

5170  Biomolecular Engineering (3) Prerequisite: Instructor's consent.
   Meets with BIOEN 7170 and 3201. Explores the use of biomolecules as new engineering materials, or as functional interfaces with conventional engineering materials. Topics include biomolecular synthesis, structure, and biological functions; protein design, methods to modify protein structure and function; applications of proteins as materials and as transducers; and goals and opportunities in biomolecular engineering.

5201  Biomechanics (4) Prerequisite: MATH 2250 and PHYS 2210. Fulfills Quantitative Intensive BS.
   Fundamental principles of mechanics applied to the study of biological systems. Passive mechanical behaviors of biological materials, measurement of nonlinear strain in tissues, arterial flow, mechanical interactions of implants with tissue, skeletal muscle mechanics, segmental biomechanics, and control of motion. Includes laboratory experience in material covered in lecture.

5301  Introduction to Modern Biomaterials (4) Cross listed as MSE 5040, PHCEU 6020. Prerequisite: MATH 2250, PHYS 2210, BIOL 2020, and CHEM 1210.
   This course is designed to introduce students to the various classes of biomaterials in use and their application in selected subspecialties of medicine including an understanding of material bulk and surface properties, standard characterization tools, the various biological responses to implanted materials, the clinical context of their use, manufacturing processes, and issues dealing with cost, sterilization, packaging, and design of biomedical devices. It also addresses professional and ethical responsibility encountered in designing medical implants.

5401  Medical Imaging Systems (3)
   Medical imaging offers a means to noninvasively visualize the anatomy and/or physiology of the body, and plays a vital role in the detection, diagnosis and monitoring under therapy of diseases. The course provides an overview of the underlying physics, image formation theories, and selected applications of major imaging systems, including x-ray, computed tomography, ultrasound, nuclear medicine, and magnetic resonance imaging.

5460  Engineering Aspects of Clinical Medicine: Theory and Practice (2)
   The course acquaints upper level undergraduate and beginning graduate students with the role technology plays in everyday clinical practice. Five or six different medical technologies, such as joint replacements, medical imaging, gait analysis, etc., will be explored. For each, the nature of the clinical condition being treated will be presented along with an explanation of the physical and engineering principles behind the technology being used to treat or diagnose the condition. The following week, the class will visit the appropriate clinic to observe the procedure and discuss what is going on from a clinical, ethical, and societal point of view with an attending physician.

5480  Principles of Ultrasound (3) Cross listed as ECE 5480. Prerequisite: PHYS 2220.
   Acoustic-wave propagation in biological materials with examples of practical medical instrumentation resulting from ultrasound interactions with biological structures. Includes one lab experience.

5900  Special Topics (1 to 4) Prerequisite: See department.
   One-time courses in highly specialized areas of biomedical engineering not covered by department or university curricula, provided by visiting faculty, regular faculty, and/or members of the biomedical industrial community.

5950  Independent Studies in Biomedical Engineering (1 to 3) Prerequisite: Instructor's consent.
   Independent projects in biomedical engineering determined by student and faculty supervisor.

6000  Systems Physiology I: Cardiovascular, Respiratory... (4) Cross listed as PHYSL 6000. Prerequisite: BIOEN 3102 or Equivalent
   Open to medical and other graduate students. Emphasizes physiological principles of major organ systems such as cardiovascular, renal and respiratory. Course includes 1 credit hour lab work covering material in lecture. Lab fee $50.

6001  Biophysics (4)
   This intermediate-level 4 credit-hour course is focused on the application of physical principles to 1) develop quantitative understanding of biophysical processes in natural and engineered molecules, membranes, tissues and organs and to 2) apply biophysical principles to the solution of biomedical engineering problems related to health and the human condition. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6002  Molecular Biophysics (3)
   This intermediate-level 3 credit-hour course is focused on the application of physical principles to: 1) develop quantitative understanding of biophysical processes in natural and engineered macromolecules, membranes, and tissues, 2) learn about modern biophysical methods capturing single molecule properties, and to 3) apply biophysical principles to the solution of biomedical engineering problems.

6003  Cellular Biophysics and Electrophysiology (3) Cross listed as PHYSL 6003. Prerequisite: BIOEN 6000 or equivalent or consent of instructor.
   This is the expanded cellular component of BIOEN 6460. Covers membrane and cellular biophysics and electrophysiology of excitable membranes in heart and brain. BIOEN 6460 has been a successful course for 5 years and this course is response to the demand for more coverage of cellular and membrane components, including both experimental and simulation/modeling aspects of the field. This course will be required component of new track in Bioengineering.

6010  Systemic Physiology II (3) Cross listed as PHYSL 6010. Prerequisite: Undergraduate course in basic systems physiology.
   This course focuses on information processing and motor control mechanisms in vertebrate and invertebrate nervous systems, and on the roles of the endocrine system in humans and insects. Students also give presentations on topics of special interest to themselves related to neural and endocrine physiology.

6050  Cellular Physiology (3) Prerequisite: BIOL 1000 and 2020 and CHEM 2310 or equivalent
   Overview of cellular organization and basic genetic mechanisms. Emphases on integrative and specialized cellular events that pertain to various organ systems. Includes 1 credit hour lab work covering material in lecture.

6060  Scientific Presentation (1)
   Students will learn how to organize and give effective written and oral technical presentations for scientific meetings.

6061  Scientific Presentation II (1)
   Continuation of BIOEN 6060. The course is designed to introduce bioengineering graduate students to standard scientific presentation formats and to forum to practice/improve oral and written communication skills. Departmental seminar attendance is required.

6062  Biomedical Engineering Literature Survey (1) Prerequisite: Instructor's consent.
   Students will read and discuss primary research literature focused within an area of biomedical engineering selected by the instructor.

6065  Biotransport (3)
   Introduces the basic principles of transport phenomena, with emphases on applying key transport concepts in the development of artificial organs and controlled drug delivery systems.

6080  Ideas into Dollars: Writing Grant Proposals (2)
   Writing, critiquing, and evaluating fundable grant proposals in science and engineering. Each student will write a full proposal during the semester.

6090  Department Seminar (0.5)
   Presentations will be made by faculty and guest speakers from outside the department and university.

6091  Department Seminar (0.5)
   Presentations will be made by faculty and guest speakers from outside the department and university.

6101  Bioinstumentation, Signals and Systems (4)
   Meets with BIOEN 5101. The fundamentals of bioinstrumentation: sources of biological signals, physics of biosignal transducers, analog and digital circuit elements, basic electrical circuit theory, signal conditioning, and signal analysis techniques. Includes laboratory experience in material covered in lecture. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6102  Bioinstrumentation Lecture (3)
   Meets with BIOEN 6101, 6101.

6140  Fundamentals of Tissue Engineering (2) Recommended Prerequisite: BIOL 1000 and MSE 2010.
   Cellular attachment, extracellular matrix biochemistry and tissue organization, cell culture, synthetic polymetric membranes, methods of cell encapsulation, biohybrid artificial organs, artificial cells, skin, bone, cartilage, liver.

6201  Biomechanics (4)
   Meets with BIOEN 5201. Fundamental principles of mechanics applied to the study of biological systems. Passive mechanical behaviors of biological materials, measurement of nonlinear strain in tissues, arterial flow, mechanical interactions of implants with tissue, skeletal muscle mechanics, segmental biomechanics, and control of motion. Includes laboratory experience in material covered in lecture. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6202  Biomechanics Lecture (3)
   Meets with BIOEN 5201, 6201.

6230  Functional Anatomy for Engineers (3) Prerequisite: Department consent required.
   Meets with ME EN 7120. Human musculo-skeletal system explored in lecture and cadaver dissection, focusing on torso, back, hip, neck and shoulder, hand, wrist, elbow, and knee. Emphasis is placed on function, biomechanics, and modeling.

6301  Biomaterials (4)
   This course is designed to introduce students to the various classes of biomaterials in use and their application in selected subspecialties of medicine including an understanding of material bulk and surface properties, standard characterization tools, the various biological responses to implanted materials, the clinical context of their use, manufacturing processes, and issues dealing with cost, sterilization, packaging, and design of biomedical devices. It also addresses professional and ethical responsibility encountered in designing medical implants. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6302  Biomaterials (3)
   Meets with BIOEN 5301, 6301.

6310  Physics of X-Ray and Ultrasound (3) Cross listed as ECE 6110.
   Physical aspects and principles of X-ray, CT and ultrasound radiology, including an overview of the hardware related to these medical-imaging modalities.

6320  Physics of Nuclear Medicine and MRI (3) Cross listed as ECE 6120.
   Physical aspects and principles of nuclear medicine and MRI, including an investigation into the design of hardware related to these medical imaging modalities.

6330  Principles of Magnetic Resonance Imaging (3) Prerequisite: BIOEN 5401 or ECE 3500 or equivalent.
   Basic principles of magnetic resonance imaging for students interested in entering MRI research. Topics covered include nuclear magnetic resonance phenomenon (origin an behavior of nuclear magnetization), theory and implementation of Fourier imaging, hardware instrumentation, and practical MRI considerations (SNR and Artifacts)

6410  Bioinstrumentation: Biosignals and Biosensors (2) Recommended Prerequisite: PHYS 5610.
   The physics of the sensors used to monitor biosignals and signal processing techniques that can present this information in a useful format.

6421  Fundamentals of Micromachining Processes (3) Cross listed as MSE 6421, ECE 6221, ME EN 6050. Prerequisite: Department consent required.
   Meets with ECE 5221 and ME EN 5050. Introduction to the principles of micromachining technologies. Topics include photolithography, silicon etching, thin film deposition and etching, electroplating, polymer micromachining, and bonding techniques. A weekly lab and a review of micromachining applications is included. Graduate students only. Extra work required.

6422  Biomedical Applications of Micromachining (2) Cross listed as ECE 5222. Prerequisite: BIOEN 6421 or ECE 5221 or ECE 6221 or ECE 6222 or MSE 5221.
   Meets with ECE 6222. Use of the technologies from the first course in the series (ECE/BIOEN 5221) to investigate biomedical applications of micromachining. Course focuses on the design and development of microsensor/actuator systems; laboratory focus is on the fabrication and testing of microscale sensor/actuator systems. Laboratory included. Undergraduate students only.

6423  Microsystems Design and Characterization (4) Cross listed as MET E 6055, MSE 6055, ECE 6225, ME EN 6055, CH EN 6659. Prerequisite: Graduate status (or instructor approval); Microsystems or semiconductor lab.
   Meets with ME EN 5055, ECE 5225, MET E 5055, MSE 5055, CH EN 5659. Third in a 3-course series on Microsystems Engineering. This course generalizes microsystems design considerations with practical emphasis on MEMS and IC characterization/physical analysis. Two lectures, one lab per week, plus 1/2 hour lab lecture. Must also register for ME EN 6056 (0-credit lab with fees). Graduate students only. Extra work required.

6430  Systems Neuroscience: Functioning of the Nervous System (4) Cross listed as NEUSC 6050.
   Understanding how the brain works is one of the deepest and most exciting challenges confronting modern science. This course will explore systems-level functioning of the nervous system, beginning with relatively concrete issues of sensory coding and motor control, and expanding into more abstract, but equally important, higher-order phenomena, such as language, cognitive and mood disorders, states of arousal, and experience-dependent modifications of neuronal operations.

6433  Biological Statistical Signal Processing (3) Prerequisites: MATH 2270 or 2250, BIOEN 5101, ECE 5540.
   This course will cover advanced topics in statistical signal processing of biological signals. The first section of the course will cover general linear models their applications to analysis of experimental data that are both univariate and multivariate. The second part of the course will cover bayesian estimation, monte-carlo simulations, time-series analysis, discrete and continuous stochastic processes, spectral estimation and time-frequency analysis. Course work will involve hands-on projects based on analysis of real biomedical signals. Pre-requisites: Digital Signal Processing, Biological Signal and Systems.

6440  Neural Engineering (3) Recommended Prerequisite: BIOEN 6010.
   Physiological, anatomical, and materials science fundamentals of electrical neuroprosthetics, the design of functional interfaces to the human nervous system.

6450  Bioengineering Control Systems (3)
   Closed-loop control theory with bioengineering applications. Z transform, stability criteria, classic closed-loop controller design and tuning, self-tuning, fuzzy logic and neural network controllers, physiological applications controlling respiration and circulation.

6460  Electrophysiology & Bioelectricity (3) Cross listed as PHYSL 6460. Prerequisite: BIOEN 6000 or equivalent or consent of instructor.
   Course content has become more focused than previous version; will concentrate on electrophysiology and bioelectricity at the tissue and whole organ level for heart and brain. Course has run successfully for 5 years; required for new BE track.

6464  Cardiac Electrophysiology and Biophysics Seminar (1) Prerequisite: BIOEN 6000, 6003, 6460 or Instructor Approval.
   This course addresses professional and ethical responsibility associated with the development, testing, and implementation of cardiac electrophysiology research. The course specifically will focus on understanding experimental model and protocol choices, with special emphasis on determining whether manuscripts rigorously follow the scientific process.

6480  Biomechanics Seminar (1) Prerequisite: Instructor's consent.
   Discussion of faculty and graduate student research in biomechanical topics. Students present progress on their research projects. Discussions of research in progress; presentation of posters or conference presentations before national meetings; and an opportunity to receive feedback on new ideas or research directions. Some knowledge of or interest in biomechanics is recommended.

6500  Mathematical Foundations of Imaging (3)
   Mathematical Foundations of Imaging, including Linear Systems, Probability and Random Variables and, Detection and Estimation Theory. Topics in Linear Systems include convolution, Fourier series and transforms, sampling and discrete-time processing of continuous-time signals. Topic in Probability and Random Variables include distribution functions, density functions, expectations, means, variances, combinatorial probability, joint distribution, independence, correlation, Bayes theorem, the law of large numbers, and the central limit theorem. Topic in Detection and Estimation Theory include detection of signals in noise, estimation of signal parameters, linear estimation theory.

6640  Introduction to Digital Image Processing (3) Cross listed as CS 6640.
   This is an introductory course in processing grey-scale images. This course will cover both mathematical fundamentals and implementation. It will introduce students to the basic principles of processing digital signals and how those principles apply to images. These fundamentals will include sampling theory, transforms and filtering. The course will also cover a series of basic image-processing problems including enhancement, reconstruction, segmentation, feature detection, and compression. Assignments will include several projects with implementations and analysis of real data.

6760  Modeling and Analysis of Biological Networks (3) Cross listed as ECE 6760, CS 6760.
   Introduction to methods for modeling and analyzing biological networks such as genetic regulatory networks, metabolic networks, and signal transduction networks. A particular emphasis will be given to methods inspired by models used by engineers for circuit analysis. Other topics include: stochastic analysis using Monte Carlo methods, differential equation models, Bayesian network models, flux balance analysis, learning methods, pathway databases, and synthesized gene circuits.

6900  Special Topics (1 to 4)
   One-time courses in highly specialized areas of biomedical engineering not covered by department or university curricula, provided by visiting faculty, regular faculty, and/or members of the biomedical industrial community.

6910  Independent Study (1 to 3) Prerequisite: Instructor's consent.
   Topics in biomedical engineering selected by student in consultation with faculty.

6920  Internship Program in Bioengineering (1 to 3) Prerequisite: Instructor's consent.
   Research projects in a nonacademic applied-bioengineering environment.

6930  Special Project (1 to 3) Prerequisite: Instructor's consent.
   Independent projects in biomedical engineering, as determined by student and faculty supervisor.

6960  Research Project: M.E. (3)

6970  Thesis Research: M.S. (1 to 12)

6980  Faculty Consultation: Master's (2 to 3)

7111  Physicochemical Approach to Proteins and Nucleic Acids (3) Cross listed as PHCEU 7410. Prerequisite: Graduate student status or instructor consent and PHCEU 7020.
   Applying physicochemical theory and molecular modeling to protein, peptide, and nucleic acid structure and stabilization.

7120  Biocompatibility (2) Cross listed as PHCEU 7210. Prerequisite: Graduate student status. Recommended Prerequisite: BIOEN 6040.
   Biocompatibility of soluble and insoluble (crosslinked) polymers. Biocompatibility of biomaterials used as implants, blood substitutes, and carriers of bioactive molecules. Biorecognition of synthetic macromolecules on cellular and subcellular levels. Biodegradability and immunogenicity of biomaterials.

7130  Pharmaceutical Applications of Colloid and Interfacial Science (2) Cross listed as PHCEU 7220.
   Colloid, interfacial, and electrokinetic theories applied to the design of drug formulations, drug delivery, and therapeutic efficacy.

7140  Advanced Topics in Tissue Engineering (2) Prerequisite: BIOEN 6140.
   The course provides advanced graduate students with an opportunity for in-depth study in a specialized area of tissue engineering. Each student works closely with the instructor to develop a comprehensive, educational oral and written presentation of a selected topic in one of the following areas: new biomaterials designed for tissue engineering; biological signals and signalling mechanisms; delivery and phenotypic expression of transplanted cells; normal and directed healing mechanisms; ontogenic development of tissues and glands; and stem cells and growth factor delivery and applications.

7150  Introduction to Biomimetic Engineering (2)
   Integration of energy transduction and transport of matter found in living systems with mimetic engineering of the same processes in laboratory. After studying selected biological examples, students design a biomimetic system that performs an identical or similar function and measures its performance. The course consists of laboratory experiments, tutorial, and a set of lectures. The tutorials are designed to teach students how to culture and use cells, design membrane mimetic surfaces using Langmuir-Blodgett trough and liposomes, use fluorescent markers and modern spectroscopic and optical microscopic techniques, such as DIC and 3-D confocal microscopy.

7155  Neural Interfaces Laboratory (3) Prerequisite: Instructor's consent.
   Engineering and implementation of neural interfaces: relevant neural properties, techniques and applications.

7160  Physical Nature of Surfaces (3) Recommended Prerequisite: BIOEN 5090.
   Concepts of surfaces and interfaces, intermolecular interactions, thermodynamics of interfaces, interface electrical potentials, electrical double layer, and electrokinetic phenomena. Basic principles of surface and interface science as applied to solid materials.

7168  Proteins at Interfaces and in Membranes (3) Recommended Prerequisite: BIOEN 5090 or CHEM 3090.
   Behavior of protein at interfaces in biological and man-made systems. Structure and dynamics of interfaces are reviewed from the protein adsorption point of view together with modern methods for studies of interfacial protein behavior. Protein adsorption models are presented from a thermodynamic and kinetic perspective. The cell adhesion is considered as a protein-mediated event. Each student is assigned a protein project in which he/she uses the molecular graphics to predict interfacial protein interactions.

7170  Biomolecular Engineering (3) Prerequisite: Instructor's consent.
   Meets with BIOEN 3201 and 5170. A course in biotechnology that explores the use of biomoleculars as new engineering materials and as functional interfaces with conventional engineering materials. Topics include: goals and opportunities in biomolecular engineering, the tools of molecular biology, protein design and engineering, and applications of proteins as materials and as transducers.

7210  Biosolid Mechanics (3) Prerequisite: MATH 3150 and ME EN 3300 Recommended Prerequisites: ME EN 5500 and ME EN 6300 and ME EN 7510.
   Constitute laws for bio-viscoelastic fluids, solids and mixtures; mechanical properties of blood vessels, ligaments, muscle, bone, and cartilage, nonlinear continuum and multiphasic models of tissues.

7220  Biofluid Mechanics (3) Prerequisite: MATH 3150 and ME EN 3700 Recommended Prerequisite: ME EN 7700 and ME EN 7710.
   Selected topics from physiological fluid dynamics, including aquatic animal propulsion, animal flight, respiratory flow patterns, blood flow and pulse propagation, rheology of blood flow in the microcirculation.

7310  Advanced Topics in Magnetic Resonance Imaging (3) Cross listed as ECE 7310, RDLGY 7310. Prerequisite: Electrical or Computer Engineering Major and instructor's consent.
   In-depth study of physics and mathematics of MR imaging and MR spectroscopy as they relate to the imaging of biologic systems: NMR physics, Block's equations, pulse sequences, flow and diffusion phenomena, spectroscopy principles, methodology. Laboratory.

7320  3-D Reconstruction Techniques in Medical Imaging (3) Cross listed as ECE 7320, RDLGY 7320. Prerequisite: Electrical or Computer Engineering Major and instructor's consent.
   The course focuses on the problem of three-dimensional (3D) image reconstruction from line integrals, which constitute a mathematical model of measurements in computed tomography (CT), and particularly x-ray computed tomography. Analytical and iterative reconstruction methods are investigated for various geometries of data acquisition. A critical goal is to provide the student with the essential tools required to understand papers on tomographic image reconstruction, from x-ray CT to emission CT, and also with a clear understanding of how efficient and accurate reconstruction algorithms are designed, using the Fourier slice theorem and backprojection techniques. MATLAB laboratories and a computer project are given in support of the theory.

7330  Modern Positron Emission Tomography (3) Cross listed as RDLGY 7330.
   The course begins with an introduction to PET imaging and physics, the image formation process, and how PET is a molecular imaging modality. Theory and algorithms for iterative tomographic image reconstruction will be introduced. The course will conclude with a study of objective measures of PET image quality, including ROC analysis methods and numerical observers. At completion, the student will have an understanding of the PET image formation process and common applications of PET imaging.

7410  Advanced Bioinstrumentation (2) Prerequisite: BIOEN 6410.
   Coverage of advanced topics in modern bioinstrumentation and measurements, including analog signal conditioning, digital processing, and electronic modules.

7420  Modeling of Physiological Systems (3)
   Models of nonlinear biological systems are derived from first principles of thermodynamics, mechanics, and chemistry. The models typically take the form of nonlinear partial differential equations, such as the reaction-diffusion of Navier-Stokes equations. Perturbation methods, bifurcation theory, and numerical methods are applied to study the behavior equations and to gain insight into the function of physiological systems.

7970  Thesis Research: Ph.D. (1 to 12)

7980  Faculty Consultation: Ph.D. (3)

7990  Continuing Registration: Ph.D. (0)