This Web document is updated twice a year, on or about the first day of registration for Fall and Spring semesters.

1102  Fundamentals of Bioengineering II (3) Co-requisite: MATH 1260 or MATH 1220 and CHEM 1220.
   This course continues the bioengineering introductory sequence. The course places an emphasis on biochemistry and bioenergetics and molecular transport, electrochemical gradients, heat and mass transport, and related topics are use to develop basic principles in cellular, organ, and systemic physiology.

1510  Science Without Walls: Science in Your World (3) Fulfills Physical/Life Science Exploration.
   A concept- and inquiry-based television course which focuses on major concepts covering to all areas of science. The course is multi- and interdisciplinary and designed primarily for nonscience majors. It connects science to daily life and activities, including the connections between the sciences, arts, and the humanities.

2000  Careers in Biomedical Engineering (1)
   NOTE: GRADING CR/NC This seminar series will introduce students to various career opportunities in the field of biomedical engineering. Guest speakers from industry, clinical practice, and research will discuss aspects of their professional practice, including global, ethical and health-care issues. Each student writes a paper on career choices of potential interest to them in biomedical engineering.

3201  An Integrated Approach to Human Physiology I (4) Prerequisite: BIOL 2020 and CHEM 2320.
   This course is the first in a two-semester sequence in Human Physiology. The 1st semester begins at the molecular scale and progresses rapidly to the systems scale. Throughout, emphasis is placed on molecular structures and mechanisms. the course has an associated laboratory with exercise related to lecture topics.

3202  An Integrated Approach to Human Physiology II (4) Prerequisite: BIOEN 3201.
   This course is the second in a two-semester sequence (BIOEN 3201, 3202, Human Physiology I, II) that teaches students to apply knowledge of mathematics, science, and engineering to cellular and systems physiology, including function, dysfunction, and the mechanisms that underlie treatment. The course also addresses professional and ethical responsibility associated with the development, testing, and implementation (or withholding) of biomedical devices or treatments. Associated laboratory modules teach students to design, conduct, and analyze experiments, and to use the techniques, skills and tools necessary for engineering practice. Topics this semester include the nervous system, striated and smooth muscle, and respiratory, renal, and cardiovascular systems.

3801  Cohort Seminar I (1) Prerequisite: Admission to accelerated program.
   Enrollment in this class is restricted to students in the accelerated program for the Dual BS/MS Degree. This seminar course is designed to help the students select a research topic, understand the research planning process (through a case-study approach), consider the ethical and societal issues involved, and learn how to conduct a literature search.

3802  Junior Seminar (1) Prerequisite: BIOEN 3801.
   This seminar course is designed to help students understand the research planning process (through a case-study approach), consider the ethical and societal issues involved, learn how to conduct a literature search, and have them select a senior project topic.

4201  Bioengineering Project I (2) Prerequisite: Restricted to students in their fourth year of the program.
   This course uses each student's required senior project as source information that the student will repeatedly present to the class in both a written and oral format. Due the communication emphasis of the class, it along with BIOEN 4202 covers the University's upper-division communication/writing requirement. During the course of the class, each student provides several oral presentations that are followed-up with instructional criticism from the class and the instructor. The students also prepare a progress report and a draft version of their final project poster at the conclusion of the semester that are critiqued and returned at the start of BIOEN 4202 for revision and resubmission.

4202  Bioengineering Project II (3) Prerequisite: BIOEN 4201. Fulfills Upper Division Communication/Writing.
   This course is a continuation of BIOEN 4201 where each student was required to present his or her senior project. The class requires each student to further refine both the oral and written presentation of his or her senior project to a professional level through additional presentations in several different time formats and through submitted drafts of his or her senior thesis. Due to the communication emphasis of the class, it along with BIOEN 4201 covers the University's upper-division communication/writing requirement. At the conclusion of the semester, each student provides a senior thesis and participates in a public senior project fair where they provide a five-minute oral presentation followed by a twenty-minute poster presentation.

4999  Honors Thesis/Project (3) Pre-requisite: BIOEN Major status.
   Restriced to students in the Honors Program working on their Honors degree.

5001  Biophysics (4) Prerequisite: MATH 2250 and PHYCS 2220. Fulfills Quantitative Intensive BS.
   This intermediate-level 4 credit-hour course is focused on the application of physical principles to 1) develop quantitative understanding of biophysical processes in natural and engineered molecules, membranes, tissues and organs and to 2) apply biophysical principles to the solution of biomedical engineering problems related to health and the human condition.

5020  Interactive Science Exhibits (1 to 3)
   An independent project course involving the design, development, implementation, and testing of interactive science/technology exhibits/activities for science centers or museums. Students may work individually or in groups.

5030  From Biology to Engineering (2)
   This directed reading/discussion project course in the area of biobased engineering is designed for advanced undergraduate and graduate students without biology backgrounds. The course rapidly surveys modern biology and then focuses on unique phenomena with potential engineering applications, such as bioluminescence, photosynthesis, bio-hydrogen, anhydrobiosis, salt glands, thermogenesis, extremophilia, electric organs, and wall-forming organisms.

5090  Biophysical Chemistry (3) Cross listed as CHEM 3090. Recommended Prerequisite: CHEM 1220 and PHYS 2220 and MATH 2210. Fulfills Quantitative Intensive BS.
   Emphasizes biological and biochemical aspects of physical chemistry.

5101  Engineering Principles in Bioinstrumentation (4) Prerequisite: PHYCS 2220, MATH 2250, BIOEN 3201 AND BIOEN 3202. Recommened prerequisites: BIOEN 5001.
   The fundamentals of bioinstrumentation: sources of biological signals, physics of biosignal transducers, analog and digital circuit elements, basic electrical circuit theory, signal conditioning, and signal analysis techniques. Includes laboratory experience in material covered in lecture.

5170  Biomolecular Engineering (3) Prerequisite: Instructor's consent.
   Explores the use of biomolecules as new engineering materials, or as functional interfaces with conventional engineering materials. Topics include biomolecular synthesis, structure, and biological functions; protein design, methods to modify protein structure and function; applications of proteins as materials and as transducers; and goals and opportunities in biomolecular engineering.

5201  Biomechanics (4) Prerequisite: MATH 2250 and PHYCS 2210. Co-requisite: MATH 1260, 2210, PHYCS 2220. Fulfills Quantitative Intensive BS.
   Fundamental principles of mechanics applied to the study of biological systems. Passive mechanical behaviors of biological materials, measurement of nonlinear strain in tissues, arterial flow, mechanical interactions of implants with tissue, skeletal muscle mechanics, segmental biomechanics, and control of motion. Includes laboratory experience in material covered in lecture.

5301  Introduction to Modern Biomaterials (4) Cross listed as MSE 5040, PHCEU 6020. Prerequisite: MATH 2250, PHYCS 2210, BIOL 2020, and CHEM 1210.
   This course is designed to introduce students to the various classes of biomaterials in use and their application in selected subspecialties of medicine including an understanding of material bulk and surface properties, standard characterization tools, the various biological responses to implanted materials, the clinical context of their use, manufacturing processes, and issues dealing with cost, sterilization, packaging, and design of biomedical devices. It also addresses professional and ethical responsibility encountered in designing medical implants.

5460  Engineering Aspects of Clinical Medicine: Theory and Practice (2)
   The course acquaints upper level undergraduate and beginning graduate students with the role technology plays in everyday clinical practice. Five or six different medical technologies, such as joint replacements, medical imaging, gait analysis, etc., will be explored. For each, the nature of the clinical condition being treated will be presented along with an explanation of the physical and engineering principles behind the technology being used to treat or diagnose the condition. The following week, the class will visit the appropriate clinic to observe the procedure and discuss what is going on from a clinical, ethical, and societal point of view with an attending physician.

5900  Special Topics (1 to 4)
   One-time courses in highly specialized areas of biomedical engineering not covered by department or university curricula, provided by visiting faculty, regular faculty, and/or members of the biomedical industrial community.

5950  Independent Studies in Biomedical Engineering (1 to 3) Prerequisite: Instructor's consent.
   Independent projects in biomedical engineering determined by student and faculty supervisor.

6000  Systemic Physiology I (3) Prerequisite: BIOEN 3102 or Equivalent
   Open to medical and other graduate students. Emphasizes physiological principles of major organ systems such as cardiovascular, renal and respiratory. Course includes 1 credit hour lab work covering material in lecture. Lab fee $50.

6001  Biophysics (4)
   This intermediate-level 4 credit-hour course is focused on the application of physical principles to 1) develop quantitative understanding of biophysical processes in natural and engineered molecules, membranes, tissues and organs and to 2) apply biophysical principles to the solution of biomedical engineering problems related to health and the human condition. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6010  Systemic Physiology II (3) Cross listed as PHYSL 6010. Prerequisite: Undergraduate course in basic systems physiology.
   This course focuses on information processing and motor control mechanisms in vertebrate and invertebrate nervous systems, and on the roles of the endocrine system in humans and insects. Students also give presentations on topics of special interest to themselves related to neural and endocrine physiology.

6050  Cellular Physiology (3) Prerequisite: BIOL 1000 and 2020 and CHEM 2310 or equivalent
   Overview of cellular organization and basic genetic mechanisms. Emphases on integrative and specialized cellular events that pertain to various organ systems. Includes 1 credit hour lab work covering material in lecture.

6060  Scientific Presentation (1)
   Students will learn how to organize and give effective written and oral technical presentations for scientific meetings.

6061  Scientific Presentation II (1)
   Continuation of BIOEN 6060. The course is designed to introduce bioengineering graduate students to standard scientific presentation formats and to forum to practice/improve oral and written communication skills. Departmental seminar attendance is required.

6080  Ideas into Dollars: Writing Grant Proposals (2)
   Writing, critiquing, and evaluating fundable grant proposals in science and engineering. Each student will write a full proposal during the semester.

6090  Department Seminar (0.5)
   Presentations will be made by faculty and guest speakers from outside the department and university.

6091  Department Seminar (0.5)
   Presentations will be made by faculty and guest speakers from outside the department and university.

6101  Bioinstumentation, Signals and Systems (4)
   Meets with BIOEN 5101. The fundamentals of bioinstrumentation: sources of biological signals, physics of biosignal transducers, analog and digital circuit elements, basic electrical circuit theory, signal conditioning, and signal analysis techniques. Includes laboratory experience in material covered in lecture. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6140  Fundamentals of Tissue Engineering (2) Recommended Prerequisite: BIOL 1000 and MSE 2010.
   Cellular attachment, extracellular matrix biochemistry and tissue organization, cell culture, synthetic polymetric membranes, methods of cell encapsulation, biohybrid artificial organs, artificial cells, skin, bone, cartilage, liver.

6201  Biomechanics (4)
   Meets with BIOEN 5201. Fundamental principles of mechanics applied to the study of biological systems. Passive mechanical behaviors of biological materials, measurement of nonlinear strain in tissues, arterial flow, mechanical interactions of implants with tissue, skeletal muscle mechanics, segmental biomechanics, and control of motion. Includes laboratory experience in material covered in lecture. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6230  Functional Anatomy for Engineers (3) Prerequisite: Department consent required.
   Human musculo-skeletal system explored in lecture and cadaver dissection, focusing on torso, back, hip, neck and shoulder, hand, wrist, elbow, and knee. Emphasis is placed on function, biomechanics, and modeling.

6301  Biomaterials (4)
   This course is designed to introduce students to the various classes of biomaterials in use and their application in selected subspecialties of medicine including an understanding of material bulk and surface properties, standard characterization tools, the various biological responses to implanted materials, the clinical context of their use, manufacturing processes, and issues dealing with cost, sterilization, packaging, and design of biomedical devices. It also addresses professional and ethical responsibility encountered in designing medical implants. The lecture portion of this course meets with senior students enrolled in the 5000 level version. Laboratory exercises and/or projects for the 6000 vs. 5000 level courses differ to accommodate the difference in level.

6310  Physics of X-Ray and Ultrasound (3) Cross listed as RDLGY 6310.
   Physical aspects and principles of X-ray and ultrasound radiology, including an overview of the hardware related to these medical-imaging modalities.

6320  Physics of Nuclear Medicine and MRI (3) Cross listed as RDLGY 6320.
   Physical aspects and principles of nuclear medicine and MRI, including an investigation into the design of hardware related to these medical imaging modalities.

6410  Bioinstrumentation: Biosignals and Biosensors (2) Recommended Prerequisite: PHYCS 5610.
   The physics of the sensors used to monitor biosignals and signal processing techniques that can present this information in a useful format.

6421  Fundamentals of Micromachining Processes (3) Cross listed as MSE 6421, ECE 6221, ME EN 6050. Prerequisite: Department consent required.
   Meets with ECE 5221 and ME EN 5050.. Introduction to the principles of micromachining technologies. Topics include photolithography, silicon etching, thin film deposition and etching, electroplating, polymer micromachining, and bonding techniques. A weekly lab and a review of micromachining applications is included.

6422  Biomedical Applications of Micromachining (2) Cross listed as ECE 5222. Prerequisite: BIOEN 6421 or ECE 5221 or ECE 6221 or ECE 6222 or MSE 5221.
   Meets with ECE 6222. Use of the technologies from the first course in the series (ECE/BIOEN 5221) to investigate biomedical applications of micromachining. Course focuses on the design and development of microsensor/actuator systems; laboratory focus is on the fabrication and testing of microscale sensor/actuator systems. Laboratory included. Undergraduate students only.

6423  Microsystems Design and Characterization (4) Cross listed as MET E 6055, MSE 6055, ECE 6225, ME EN 6055, CHFEN 6659. Prerequisite: Graduate status (or instructor approval); Microsystems or semiconductor fab.
   Meets with ME EN 5055, ECE 5960, MET E 5055, MSE 5055, CHFEN 5659. Third in a 3-course series on Microsystems Engineering. This course generalizes microsystems design considerations with practical emphasis on MEMS and IC characterization/physical analysis. Two lectures, one lab per week, plus 1/2 hour lab lecture. Must also register for ME EN 6056 (0-credit lab with fees).

6430  Systems Neuroscience: Functioning of the Nervous System (4) Cross listed as NEUSC 6050.
   Understanding how the brain works is one of the deepest and most exciting challenges confronting modern science. This course will explore systems-level functioning of the nervous system, beginning with relatively concrete issues of sensory coding and motor control, and expanding into more abstract, but equally important, higher-order phenomena, such as language, cognitive and mood disorders, states of arousal, and experience-dependent modifications of neuronal operations.

6433  Biological Statistical Signal Processing (3) Prerequisites: MATH 2270 or 2250, BIOEN 5101, ECE 5540.
   This course will cover advanced topics in statistical signal processing of biological signals. The first section of the course will cover general linear models their applications to analysis of experimental data that are both univariate and multivariate. The second part of the course will cover bayesian estimation, monte-carlo simulations, time-series analysis, discrete and continuous stochastic processes, spectral estimation and time-frequency analysis. Course work will involve hands-on projects based on analysis of real biomedical signals. Pre-requisites: Digital Signal Processing, Biological Signal and Systems.

6440  Applied Neurophysiology (2) Recommended Prerequisite: BIOEN 6010.
   Physiological, anatomical, and materials science fundamentals of electrical neuroprosthetics, the design of functional interfaces to the human nervous system.

6450  Bioengineering Control Systems (3)
   Closed-loop control theory with bioengineering applications. Z transform, stability criteria, classic closed-loop controller design and tuning, self-tuning, fuzzy logic and neural network controllers, physiological applications controlling respiration and circulation.

6460  Electrophysiology & Bioelectricity (3) Prerequisite: Permission of instructor required.
   The goal of this class is to provide an overview of electrophysiology and bioelectricity to graduate students with special interest in cardiology and neurosciences. We will develop the central electrical mechanisms from the membrane channel to the intact organ, building on those that are common to many electrically active cells in the body. The approach will be a combination of qualitative explanations, quantitative analysis, and mathematical simulation. The class format will include didactic lectures, group discussion of primary literature, student presentations, quantitative problem solving exercises, writing assignments, and laboratory experiences. The prerequisite for the course is the permission of the instructor; strongly recommended background knowledge includes previous exposure to basic electrophysiology (e.g., Bioengineering 6000/6010 or equivalent), university level calculus and physics. Homework assignments will require the use of Matlab and electronic submission of reports.

6470  Ultrasound (2) Cross listed as ECE 5470.
   Acoustic-wave propagation in biological materials with examples of practical medical instrumentation resulting from ultrasound interactions with biological structures. Includes one lab experience.

6480  Biomechanics Seminar (1) Prerequisite: Instructor's consent.
   Discussion of faculty and graduate student research in biomechanical topics. Students present progress on their research projects. Discussions of research in progress; presentation of posters or conference presentations before national meetings; and an opportunity to receive feedback on new ideas or research directions. Some knowledge of or interest in biomechanics is recommended.

6900  Special Topics (1 to 4)
   One-time courses in highly specialized areas of biomedical engineering not covered by department or university curricula, provided by visiting faculty, regular faculty, and/or members of the biomedical industrial community.

6910  Independent Study (1 to 3) Prerequisite: Instructor's consent.
   Topics in biomedical engineering selected by student in consultation with faculty.

6920  Internship Program in Bioengineering (1 to 3) Prerequisite: Instructor's consent.
   Research projects in a nonacademic applied-bioengineering environment.

6930  Special Project (1 to 3) Prerequisite: Instructor's consent.
   Independent projects in biomedical engineering, as determined by student and faculty supervisor.

6960  Research Project: M.E. (3)

6970  Thesis Research: M.S. (1 to 12)

6980  Faculty Consultation: Master's (2)

7111  Physicochemical Approach to Proteins and Nucleic Acids (3) Cross listed as PHCEU 7410. Prerequisite: Graduate student status or instructor consent and PHCEU 7020.
   Applying physicochemical theory and molecular modeling to protein, peptide, and nucleic acid structure and stabilization.

7120  Biocompatibility (2) Cross listed as PHCEU 7210. Prerequisite: Graduate student status. Recommended Prerequisite: BIOEN 6040.
   Biocompatibility of soluble and insoluble (crosslinked) polymers. Biocompatibility of biomaterials used as implants, blood substitutes, and carriers of bioactive molecules. Biorecognition of synthetic macromolecules on cellular and subcellular levels. Biodegradability and immunogenicity of biomaterials.

7130  Pharmaceutical Applications of Colloid and Interfacial Science (2) Cross listed as PHCEU 7220.
   Colloid, interfacial, and electrokinetic theories applied to the design of drug formulations, drug delivery, and therapeutic efficacy.

7140  Advanced Topics in Tissue Engineering (2) Prerequisite: BIOEN 6140.
   The course provides advanced graduate students with an opportunity for in-depth study in a specialized area of tissue engineering. Each student works closely with the instructor to develop a comprehensive, educational oral and written presentation of a selected topic in one of the following areas: new biomaterials designed for tissue engineering; biological signals and signalling mechanisms; delivery and phenotypic expression of transplanted cells; normal and directed healing mechanisms; ontogenic development of tissues and glands; and stem cells and growth factor delivery and applications.

7150  Introduction to Biomimetic Engineering (2)
   Integration of energy transduction and transport of matter found in living systems with mimetic engineering of the same processes in laboratory. After studying selected biological examples, students design a biomimetic system that performs an identical or similar function and measures its performance. The course consists of laboratory experiments, tutorial, and a set of lectures. The tutorials are designed to teach students how to culture and use cells, design membrane mimetic surfaces using Langmuir-Blodgett trough and liposomes, use fluorescent markers and modern spectroscopic and optical microscopic techniques, such as DIC and 3-D confocal microscopy.

7155  Neural Interfaces Laboratory (3) Prerequisite: Instructor's consent.
   Engineering and implementation of neural interfaces: relevant neural properties, techniques and applications.

7160  Physical Nature of Surfaces (3) Recommended Prerequisite: BIOEN 5090.
   Concepts of surfaces and interfaces, intermolecular interactions, thermodynamics of interfaces, interface electrical potentials, electrical double layer, and electrokinetic phenomena. Basic principles of surface and interface science as applied to solid materials.

7168  Proteins at Interfaces and in Membranes (3) Recommended Prerequisite: BIOEN 5090 or CHEM 3090.
   Behavior of protein at interfaces in biological and man-made systems. Structure and dynamics of interfaces are reviewed from the protein adsorption point of view together with modern methods for studies of interfacial protein behavior. Protein adsorption models are presented from a thermodynamic and kinetic perspective. The cell adhesion is considered as a protein-mediated event. Each student is assigned a protein project in which he/she uses the molecular graphics to predict interfacial protein interactions.

7170  Biomolecular Engineering (3) Prerequisite: Instructor's consent.
   A course in biotechnology that explores the use of biomoleculars as new engineering materials and as functional interfaces with conventional engineering materials. Topics include: goals and opportunities in biomolecular engineering, the tools of molecular biology, protein design and engineering, and applications of proteins as materials and as transducers.

7210  Biosolid Mechanics (3) Prerequisite: MATH 3150 and ME EN 3300 Recommended Prerequisites: ME EN 5500 and ME EN 6300 and ME EN 7510.
   Constitute laws for bio-viscoelastic fluids, solids and mixtures; mechanical properties of blood vessels, ligaments, muscle, bone, and cartilage, nonlinear continuum and multiphasic models of tissues.

7220  Biofluid Mechanics (3) Prerequisite: MATH 3150 and ME EN 3700 Recommended Prerequisite: ME EN 7700 and ME EN 7710.
   Selected topics from physiological fluid dynamics, including aquatic animal propulsion, animal flight, respiratory flow patterns, blood flow and pulse propagation, rheology of blood flow in the microcirculation.

7310  Advanced Topics in Magnetic Resonance Imaging (3) Cross listed as ECE 7310, RDLGY 7310. Prerequisite: Electrical or Computer Engineering Majors and instructor's consent.
   In-depth study of physics and mathematics of MR imaging and MR spectroscopy as they relate to the imaging of biologic systems: NMR physics, Block's equations, pulse sequences, flow and diffusion phenomena, spectroscopy principles, methodology. Laboratory.

7320  3-D Reconstruction Techniques in Medical Imaging (3) Cross listed as ECE 7320, RDLGY 7320. Prerequisite: Electrical or Computer Engineering Majors and instructor's consent.
   Physics and mathematics of three-dimensional reconstruction techniques in medical imaging: projection slice theorem, back-projection techniques, analytical and iterative reconstruction alogrithms, numerical methods; applications in X-Ray CT, SPECT, PET, and NMR. Laboratory.

7410  Advanced Bioinstrumentation (2) Prerequisite: BIOEN 6410.
   Coverage of advanced topics in modern bioinstrumentation and measurements, including analog signal conditioning, digital processing, and electronic modules.

7420  Modeling of Physiological Systems (3)
   Models of nonlinear biological systems are derived from first principles of thermodynamics, mechanics, and chemistry. The models typically take the form of nonlinear partial differential equations, such as the reaction-diffusion of Navier-Stokes equations. Perturbation methods, bifurcation theory, and numerical methods are applied to study the behavior equations and to gain insight into the function of physiological systems.

7970  Thesis Research: Ph.D. (1 to 12)

7980  Faculty Consultation: Ph.D. (3)

7990  Continuing Registration: Ph.D. (0)